Search results for " GALACTOSYLATION"

showing 2 items of 2 documents

Galactose-decorated polymeric nanoparticles based on a polyaspartamide

2013

GALACTOSYLATIONTARGETED DELIVERYPHEAPHEA; GALACTOSYLATION; TARGETED DELIVERYPHEA GALACTOSYLATION TARGETED DELIVERY
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Galactosylated polymeric carriers for liver targeting of sorafenib

2014

In this paper, we describe the preparation of liver-targeted polymeric micelles potentially able to carry sorafenib to hepatocytes for treatment of hepatocarcinoma (HCC), exploiting the presence of carbohydrate receptors, ASGPR. These micelles were prepared starting from a galactosylated polylactide-polyaminoacid conjugate. This latter was obtained by chemical reaction of α,β-poly(N-2-hydroxyethyl) (2-aminoethylcarbamate)-d,l-aspartamide (PHEA-EDA) with polylactic acid (PLA), and subsequent reaction with lactose, leading to PHEA-EDA-PLA-GAL copolymer. Liver-targeted sorafenib-loaded micelles were obtained in aqueous media at low PHEA-EDA-PLA-GAL copolymer concentration value with nanometer …

NiacinamideSorafenibBiodistributionPolyestersBiological AvailabilityPharmaceutical ScienceAntineoplastic AgentsPharmacologyKidneyMicellechemistry.chemical_compoundPolylactic acidHepatic cell-targeted carriersmedicineZeta potentialAnimalsLungneoplasmsMicellesDrug CarriersActive targetingPhenylurea CompoundsHepatic cell-targeted carrierGalactoseActive targeting; Galactosylation; Hepatic cell-targeted carriers; Polymeric micellesSorafenibEthylenediaminesdigestive system diseasesMice Inbred C57BLLiverBiochemistrychemistrySettore CHIM/09 - Farmaceutico Tecnologico ApplicativoGalactosylationDrug deliveryPolymeric micellesFemalePeptidesDrug carrierSpleenmedicine.drugConjugateInternational Journal of Pharmaceutics
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